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How the vaccines we have — and the ones coming next — stack up against COVID-19 variants

How the vaccines we have — and the ones coming next — stack up against COVID-19 variants

Infectious disease specialist Dr. Zain Chagla breaks down the entire lot you favor to understand about the five leading COVID-19 vaccines and how they work — or don’t — against the variants of mission.

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Well being Canada has permitted two COVID-19 vaccines, Moderna and Pfizer-BioNTech, and approvals on three more are anticipated in the coming months. (Evan Mitsui/CBC)

The Dose20: 52What vaccines are coming next and how effective will they be against the COVID-19 variants?

Whereas national-level COVID-19 knowledge shows a downward style in on each day foundation case numbers, eight provinces have reported sufferers contaminated with pertaining to unusual variants — the more transmissible traces of the coronavirus. 

Infectious disease experts sigh the B117 strain, in the starting put came upon in the U.K., and the B1351 strain, in the starting put came upon in South Africa, are as valuable as 50 per cent more transmissible. In Ontario, as an illustration, public health officers have talked about B117 will likely be the dominant strain in a matter of weeks.

But Dr. Zain Chagla, an infectious disease doctor for St. Joseph’s Healthcare in Hamilton, Ont., talked about there’s station off of hope.  He told Dr. Brian Goldman, host of The Dose and White Coat, Dusky Art work, that he’s optimistic on story of 5 diversified vaccines have been submitted to Well being Canada for approval, and each and every could well well even play a characteristic in controlling the variants. 

“A year ago I consider having conferences on each day foundation in the health center asserting, ‘When is this coming to Canada?’ ‘How are we going to handle it?'” talked about the affiliate professor of treatment at McMaster University. “How are we going to handle it? You already know, seeing these apocalyptic photography out of China and Italy, vivid that that changed into going to be here. And now, a year later, we’re … speaking about five vaccines.

“The human spirit is amazing.”

Dr. Zain Chagla, an infectious disease doctor for St. Joseph’s Healthcare in Hamilton, Ont., and affiliate professor of treatment at McMaster University, says he remains optimistic the present vaccines can fight the COVID-19 variants. (Craig Chivers/CBC)

Well being Canada has permitted two COVID-19 vaccines, Moderna and Pfizer-BioNTech, and three more will likely be permitted in coming months.

Right here is how the five photos review and what we know up to now about how they fare in the fight against the more infectious variants. 

Pfizer-BioNTech & Moderna 

Both Pfizer-BioNTech and Moderna sigh their vaccines seem like effective against both the B117 and the B1351 traces, basically based on blood samples from folks who have been vaccinated. 

In a assertion, Pfizer-BioNTech talked about these preliminary findings “enact no longer demonstrate the need for a unusual vaccine to contend with the rising variants.”

Chagla talked about, fortuitously, both of these vaccines seem like maintaining against B117 as it be the variant spreading the most swiftly in Canada.

However, as the clinical trials of both Moderna and Pfizer-BioNTech were performed earlier than explicit variants of mission took off, more review is mandatory to gather elevated quality knowledge.

A comparability of the efficacy of the five leading COVID-19 vaccines against both the dominant strain of COVID-19 and two key variants, B117 and B1531. (Graphic by Ben Shannon/CBC)



In the final levels of overview, the Oxford-AstraZeneca vaccine is anticipated to be the next method permitted by Well being Canada. 

Chagla talked about the vaccine is set 70 per cent effective against the non-variant strain, basically based on slack stage clinical knowledge released by AstraZeneca.

The knowledge isn’t any longer so sizable by the variants. This week, South Africa paused share of its rollout of the AstraZeneca vaccine after knowledge from a itsy-bitsy trial showed it did no longer protect against restful to common illness from the B1351 variant now dominant in the country.

But Chagla talked about it be essential to place this knowledge in context, and that more review is mandatory. 

“You mute destroy no longer have steady knowledge or substandard knowledge by if these vaccines mute prevent hospitalizations and death,” he talked about.

If it looks the vaccine does a steady job of combating extreme cases, “it would possibly well perhaps mute be a vital intervention there,” Chagla talked about.

On Wednesday, a World Well being Group panel talked about the vaccine is safe and effective and must always mute be used broadly, even in worldwide locations where the B1351 variant is dominant. 

Johnson & Johnson

Johnson & Johnson submitted its one-shot vaccine for approval in the U.S. final week. 

The company says its Segment 3 clinical trial knowledge showed the vaccine is overall 66 per cent effective at combating common to extreme COVID-19.

Chagla talked about there’s plenty of hope with this vaccine, despite the lower overall efficacy price when put next to Moderna and Pfizer-BioNTech’s vaccines which have around 95 per cent efficacy.

He talked about the proven fact that it is going to also furthermore be kept in a frequent fridge and is hotfoot in precisely one dose method the Johnson & Johnson vaccine will likely be a sport-changer. 

“It will no longer be as efficacious as Pfizer, but perfection is the enemy of steady,” Chagla told Goldman.

“If we had the entire Canadian inhabitants have a dose of Johnson & Johnson tomorrow, vivid that in 40 days, most folks would no longer be hospitalized or die from COVID-19, I possess all of us would breathe a immense dispute of reduction.”

WATCH | Why the single-shot logistics of Johnson & Johnson’s vaccine matter:

Calling the clinical trial ‘thorough,’ infectious disease specialist Dr. Matthew Oughton says Johnson & Johnson’s single-shot COVID-19 vaccine will likely be less difficult to handle logistically when put next to permitted vaccines in Canada. 3: 40


Novavax is a two-dose vaccine that will well well even furthermore be kept at frequent fridge temperature.

The company talked about early findings from U.K. review demonstrate its vaccine gave the impression to be 86 per cent effective against B117 and 60 per cent effective against B1351.

“This is an incredibly essential vaccine for both [U.K. and South African] settings and very, very promising for B117, as well as what’s circulating here in Canada on the entire,” talked about Chagla.

Canada has signed an settlement for Novavax to possess tens of hundreds of thousands of doses of its COVID-19 vaccine in Canada as soon as it be permitted by Well being Canada.

No ‘most effective’ vaccine

In a couple of months, Canada could well well even have five diversified vaccines going into fingers, and Chagla talked about there is nobody “most effective” vaccine amongst them.

“The most effective vaccine is the one which’s administered. Every Canadian must always mute be hopeful that they can receive with no doubt one of these vaccines, period.”

Chagla talked about the next few months are serious. Until ample folks have got their photos, Canadians prefer to hang tight and continue to socially distance, take care of dwelling as valuable as that you have to well perhaps most probably take into consideration, wear masks and be aware public health pointers. 

But he’s optimistic better days are coming. 

“With any luck, we can discuss a summer season and a fall that is getting abet to normal.”

Written and produced by Willow Smith 

How the vaccines we have — and the ones coming next — stack up against COVID-19 variants